Success Stories:
Genetic Syndromes

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Normalizing Neural Connections

Specific activities are recommended and implemented in each individualized model of care to normalize connections within the brain. The areas of focus have been observed as under-utilized or over-active through qEEG analysis.

Genetic Syndromes

Student Name: Eli
Age: 6
Diagnosis: SCN2a gene mutation

Functional Challenges: Eli entered Jacob's Ladder with extreme levels of sensory over-processing and uncoordinated and involuntary movements. He had no language ability and could not stand or walk.

We identified and measured where communication flow was lacking in Eli's brain (hypo-coherence) or was locked and overly used (hyper-coherence) using comprehensive evaluations, including a qEEG brain map.

This assessment served as the basis for his individualized model of care, which focused on the top 10 regions of Eli’s brain that were under-utilized and the top 10 that were over-utilized to normalize neural connections. Eli's goals included:

Goal #1: Communicate needs, wants, and feelings appropriately.

Goal #2: Comply with routines and understand expectations.

Goal #3: Self-regulate behaviors.

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"Communication has always been a goal and we’ve tried varied things and not all of them have worked. He is now more assertive and proactive and he has found his voice – there is a different quality about his desire and willingness to communicate. He has made a lot of gains physically too – a lot of progress using his walker; he literally got up from a seated position on the ground, went to his walker and turned around and was able to use it – and he learned all of that here.”

- Eli’s Parents

Eli's Program and Functional Gains

Within eight months, Eli’s individualized plan of therapeutic interventions and brain stimulation helped him dramatically increase motor control and sensory-regulation abilities. He began to communicate with a letterboard device, bear his own weight, and take initial steps independently. Eli and his provider worked hard to create spaces supporting his learning style and goals. Daily behavior measurements helped his family track progress and celebrate many breakthroughs along his journey.

Starting at Jacob's Ladder

  1. Extreme levels of over-processing sensory information

  2. Uncoordinated and involuntary movements

  3. No functional language – either receptive or expressive communication patterns

  4. No ability to stand, weight-bear, or walk

8 Months Later

  1. Dramatic increase in sensory- regulation abilities

  2. Increase in motor control with substantial decrease in involuntary muscle activity

  3. Ability to functionally communicate with a letterboard device

  4. Weight-bearing and taking initial steps independently

Eli's Brain Improvement

Eli experienced tremendous gains in mobility and relational functioning as he developed the proper connections between areas in his brain. Below are examples of neural connection improvements, as shown through qEEG measurements.

The communication flow between the Orbital Frontal Lobe and Anterior Cingulate Gyrus lacked -7.10 standard deviations from a normalized connection.

Through Eli's individualized model of care, activities were implemented that improved the communication flow to -2.26 standard deviations from a normalized connection.


The communication flow between the Occipital Cortex and the Posterior Cingulate Gyrus was locked and overly-used by +4.59 standard deviations from a normalized connection.

Through Eli's individualized model of care, activities were implemented that improved the communication flow to -2.51 standard deviations from a normalized connection.


Areas of Focus

Orbital Frontal Lobe (Left)
  • Planning and evaluating goal directed behavior
  • Making inferences of other people
  • Modulation of affect: empathy, consequences of actions, self-expression, problem solving
  • Executive functioning
Anterior Cingulate Gyrus​ (Left)
  • Hub of emotional brain
  • Executive network functions, reasoning
  • Verbal fluency and naming of objects
Occipital Cortex (Right)
  • Visual processing of features and patterns
  • Light intensity
  • Recognition and memory of word association for objects and faces
Posterior Cingulate Gyrus (Right)
  • Interpretation and synthesis of incoming sensory input
  • Emotional link to word meaning
  • Fear conditioning

Find out how Jacob's Ladder helps clients with genetic syndromes maximize their potential.

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407 Hardscrabble Road
Roswell, Georgia 30075

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